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Clinical Use of Stem Cells – When It Is Going to Happen

June 20, 2009 By Leave a Comment

Our goal of use of stem cells in clinical practice is far from true. An intensive research is going to realize the promise of novel cell-based therapies. There are few needs that must be fulfilled before stem cells can be used in clinical practice.

we  must be able to manipulate stem cells so that they possess the necessary characteristics for successful differentiation, transplantation, and engraftment.

The following is a list of steps in successful cell-based treatments that scientists will have to learn to control to bring such treatments to the clinic. [Read more...]

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Clinical Applications of Stem Cells – What Could Be Possible?

June 19, 2009 By Leave a Comment

Stems  cells are promise of the future. There are a number of conditions where stem cells have potential application and tere are many ways in which human stem cells can be used.

One of the primary goals of stem cells is to identify how undifferentiated stem cells become the differentiated cells that form the tissues and organs. Here are the areas where stem cells can help the medicine and human race. [Read more...]

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What Are Induced Pluripotent Stem Cells?

June 17, 2009 By Leave a Comment

Induced pluripotent stem cells (iPSCs) are adult cells that have been genetically reprogrammed to an embryonic stem cell–like state by being forced to express genes and factors important for maintaining the defining properties of embryonic stem cells.

Although these cells meet the defining criteria for pluripotent stem cells, it is not known if iPSCs and embryonic stem cells differ in clinically significant ways.

Mouse iPSCs were first reported in 2006, and human iPSCs were first reported in late 2007.

Mouse iPSCs demonstrate important characteristics of pluripotent stem cells, including expressing stem cell markers, forming tumors containing cells from all three germ layers, and being able to contribute to many different tissues when injected into mouse embryos at a very early stage in development.

Human iPSCs also express stem cell markers and are capable of generating cells characteristic of all three germ layers.

Although additional research is needed, iPSCs are already useful tools for drug development and modeling of diseases, and scientists hope to use them in transplantation medicine. [Read more...]

Filed Under: Stem Cell Basics

Fibrin Microbead – Would It Improve Clinical Application of Stem Cells

June 17, 2009 By Leave a Comment

One of the major difficulty in stem cell linical application is the inability of cellular structures to integrate and survive and repair the damaged target tissues. Injected single cells also survive poorly and can hardly integrate in tissues.

A  practical solution is to deliver the cells on small particulate matrix, in a manner that can allow their integration in the tissues. Fibrin micro-beads  has  higher cell binding capability than native fibrin gel. FMB bind matrix dependent cells and this may be used for the isolation of mesenchymal stem cells. [Read more...]

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What Is A Stem Cell bank

June 13, 2009 By Leave a Comment

A cell bank in its simplest form is a collection of containers of cryopreserved cells that are intgral part of a homogenous cell suspension derived from a single culture of cells.Cells are stored at ultra-low temperature and in this state the cells remain viable indefinitely. On thawing they are able to divide again.

A cryopreserved bank of cells is a kind of freezed culture. The cells can be characterised, qualified
and shared. [Read more...]

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Link Between Stem Cells and Regenerative medicine

June 10, 2009 By Leave a Comment

Regenerative medicine was the term coined by William A. Haseltine in 2000. This  tries to heal the body by stimulation of endogenous cells to repair damaged tissues, or transplantation of cells or engineered tissues to replace diseased or injured.

Tissue injuries are normally repaired by formation of fibrous scar tissue in humans. But a number of tissues in mammals including epithelia, bone marrow, and muscle undergo regeneration to keep tissue integrity after cell loss .

Some lower animals can undertake full organ regeneration.Though not entirely clear, two  mechanisms play roles in regeneration. [Read more...]

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A Protein That Induces Stem Cells Found To Stimulate Muscle Regeneration

June 9, 2009 By Leave a Comment
body_building

body_buildingA protein called Wnt7a has been found to increase the number of stem cells in muscle tissue, leading to accelerated growth and repair of skeletal muscle. This has been found in a study research at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa.

The finding shows that, by targeting stem cells to boost their numbers, we can improve the body’s ability to repair muscle tissue, senior author Dr. Michael Rudnicki was reported saying.

Rudnicki is the scientific director of Canada’s Stem Cell Network and a professor of medicine at the University of Ottawa.

[Read more...]

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International Policy on Human Embryonic Stem Cell Research

June 8, 2009 By Leave a Comment
parliament

parliamentThe policies on human embryonic stem cell   research used by different countries vary tremendously and change frequently. The policies are determined by the government stand religious stand and political awareness etc.

Here is major categorization

Permissive:

This policy allows various embryonic stem cell derivation techniques including somatic cell nuclear transfer (SCNT), also called research or therapeutic cloning. [Read more...]

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Embryonic Stem Cells and Regenerative Medicine

June 5, 2009 By Leave a Comment

Under appropriate culture conditions, embryonic have demonstrated a remarkable ability to self-renew continuously, that is, to produce more cells like themselves that are multipotent.

Human embryonic stem cells that have been propagated for more than two  years also demonstrate a stable and normal complement of chromosomes. This is in contrast to the unstable and abnormal complement of embryonic cancer cell lines used in the past.

Research on human embryonic stem cells is very recent. The data about properties of stem cells comes from mice. [Read more...]

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Hematopoietic Stem Cells – An Alternative?

June 4, 2009 By Leave a Comment

Role of bone marrow transplants in increasing the survival of patients with leukemia and other cancers, inherited blood disorders, and diseases of the immune system and it is an inspiration to stem cell research.

Hematopoietic stem cells are used in bone marrow transplant and have the ability to self renew in the marrow and to differentiate into the full complement of cell types found in blood. [Read more...]

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