Hematopoietic Stem Cells – An Alternative?

Role of bone marrow transplants in increasing the survival of patients with leukemia and other cancers, inherited blood disorders, and diseases of the immune system and it is an inspiration to stem cell research.

Hematopoietic stem cells are used in bone marrow transplant and have the ability to self renew in the marrow and to differentiate into the full complement of cell types found in blood. [Read more...]

Adult Stem cells versus Embryonic Stem Cells

Apart from the differences in sources human embryonic and adult stem cells each offer advantages and disadvantages when channeled for potential use for cell-based regenerative therapies.

They differ in number and type differentiated cell types they can become.

Differentiation Capacity

While embryonic stem cells can become all cell types of the body because they are pluripotent, adult stem cells are  limited to differentiating into their tissue of origin. [Read more...]

What Are Adult Stem Cells and Where Are They Found?

An adult stem cell is an undifferentiated cell found among differentiated cells in a tissue or organ. These cells  can renew themselves  and can differentiate to yield the major specialized cell types of the tissue or organ.

The primary roles of adult stem cells in a living organism are to maintain and repair the tissue in which they are found.

They are also termed as  somatic stem cell. The origin of adult stem cells in mature tissues is unknown.

Adult stem cells have been found in many more tissues than they once thought possible. In right environment, certain kinds of adult stem cells seem to have the ability to differentiate into a number of different cell types, given the right conditions. If this is possible under lab conditions, these cells may become the basis of therapies for many serious common diseases.

About 40 years ago, researchers discovered that the bone marrow contains at least two kinds of stem cells. One population, called hematopoietic stem cells, forms all the types of blood cells in the body. A second population, called bone marrow stromal cells, generate bone, cartilage, fat, and fibrous connective tissue.

There are a very small number of stem cells in each tissue.They may remain non-dividing for many years until they are activated by disease or tissue injury.

The adult tissues reported to contain stem cells include brain, bone marrow, peripheral blood, blood vessels, skeletal muscle, skin and liver.

Struggle, however is to  grow adult stem cells in cell culture and manipulate them to generate specific cell types so they can be used to treat injury or disease.

How To Identify Adult Stem Cells?

One or more of the following three methods are used to identify adult stem cells

  1. Labeling the cells in a living tissue with molecular markers and then determining the specialized cell types they generate
  2. Removing the cells from a living animal, labeling them in cell culture, and transplanting them back into another animal to determine whether the cells repopulate their tissue of origin
  3. Isolating the cells, growing them in cell culture, and manipulating them, often by adding growth factors or introducing new genes, to determine what differentiated cells types they can become.

What Are Stem Cells?

Stem cells are special types of cells which have the characteristic ability to renew themselves through mitotic cell division [ A kind of cell division in which two similar cells are produced from one cell] and differentiating into a diverse range of specialized cell types.

Stem cells are present in most multi-cellular organisms.

The two broad types of mammalian stem cells are

  • Embryonic stem cells
    These cells are isolated from the inner cell mass of blastocysts in embryo.In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues.
  • Adult stem cells
    These are found in adult tissues and participate in  repair system for the body, replenish specialized cells and maintain the normal turnover of regenerative organs, such as blood, skin or intestinal tissues.

Stem cells can now be grown and transformed into specialized cells with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture.

Highly plastic adult stem cells from a variety of sources, including umbilical cord blood and bone marrow, are routinely used in medical therapies. Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning are promising candidates for future therapies.